VEGFA and hypertensive disorder: In preeclampsia, excessive sFLT1 production and secretion from the placenta leads to elevated serum sFLT1, reducing free serum levels of VEGF and PlGF, inhibiting VEGF-mediated vasodilation and angiogenesis, causing hypertension and damaging vasculature.21 While we do not focus on pathology here, a quantitative understanding of sFLT1 production and secretion from endothelial cells could be extended in the future to simulate pathologies.