By measuring T cell phenotype and MMRd spheroid killing following coculture with MonoMacs from tumor or LN of mice bearing CT26 MSH2 KO tumors treated with anti-PD-1 or anti-PD-1/LAG3/CTLA4/TREM2, we observed an increase in T cell activation and tumor spheroid killing following coculture with MonoMacs from mice treated with anti-PD-1/LAG3/CTLA4/TREM2 (Extended Figure 19). This evidence concerns the gene CTLA4 and neoplasm.