KSHV is the causative agent of Kaposi’s sarcoma1, 2, two human lymphoproliferative diseases, primary effusion lymphoma (PEL)3, 4, AIDS-related multicentric Castleman’s disease (MCD)5, 6, and a more recently described interleukin-6 related disease, KSHV-inflammatory cytokine syndrome (KICS)7, 8. Here, IL6 is linked to primary effusion lymphoma.