To further investigate this phenomenon, we examined three diverse cancer cell lines that harbored MYC/PVT1 amplification and PVT1 translocations: COLO-320DM (colorectal cancer), SK-PN-DW (primitive neuroectodermal tumor (PNET)), and D458 (medulloblastoma (MB)). The gene discussed is PVT1; the disease is cancer.