Additional evidence of PVT1 breakpoints leading to PVT1 promoter-MYC fusions on extrachromosomal circular DNA (ecDNA), fostering unregulated enhancer input to drive MYC transcription have also strengthened the MYC-PVT1 co-operation in MYC+ cancers 48, 49, 50, 51. The gene discussed is PVT1; the disease is cancer.