CHKA and congenital muscular dystrophy due to LMNA mutation: In mammals, mutations in choline kinase controlling initial steps in PC synthesis are associated with changes in mitochondrial morphology and mitophagy in mouse muscle tissue (50) and human disease (Congenital muscular dystrophy with mitochondrial structural abnormalities, CMDmt), underscoring the importance of understanding these links between metabolism, mitophagy and stress resistance/lifespan.