MAPT and neurodegenerative disease: Interestingly, Pb has also been implicated in hyperphosphorylation of Tau (Gąssowska et al., 2016) and this molecular alteration to Tau has been well characterized in the generation of neurofibrillary tangles (Bussian et al., 2018), a major indicator of neurodegenerative disease (Lee et al., 2001).