To evaluate further effects of ABE on human vascular cells, endothelial dysfunction, and other cardiovascular HGPS pathologies, we tested the maximum possible benefit of base editing on HGPS TEBVs by transducing HGPS iPSCs with ABE7.10max sgPro, an ABE designed to target the HGPS mutation in LMNA locus and revert it to the wild-type allele. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.