We have also identified a MYH11 rare variant of unknown significance (VUS), MYH11 p.Arg247Cys, in patients with thoracic aortic disease, and disruption of the corresponding amino acid in MYH7 causes familial hypertrophic cardiomyopathy (8, 9). Here, MYH11 is linked to familial hypertrophic cardiomyopathy.