This process is often accompanied by the release of various neurotransmitters, including CGRP, pituitary adenylate cyclase-activating polypeptide (PACAP 38), glutamate, and nitric oxide (NO), which lead to peridural vasodilation, plasma protein extravasation, and mast cell degranulation, thereby triggering a series of neurogenic inflammatory responses that result in migraine (Dodick, 2018). This evidence concerns the gene ADCYAP1 and migraine disorder.