A recent clinical study involving 226 migraine patients and 452 non-migraine control subjects elucidated the role of PI3K/Akt signaling pathway-related genes in migraine, identifying novel associations of RASGRP2-rs2230414, PIK3R1-rs3730089, CACNA1H-rs61734410, PRKCA-rs2286674, and G6PC2-rs3732033 with migraine susceptibility (Wang et al., 2024). This evidence concerns the gene PIK3R1 and migraine disorder.