PLAT and atrial fibrillation: Among the 27 drugs targeting PLG, eight activators (Urokinase, Reteplase, Streptokinase, Alteplase, Anistreplase, Tenecteplase, Desmoteplase, and Defibrotide sodium) were particularly noteworthy, as low PLG levels were inferred to be causal for both MI and AF.