IL1RN and hypertensive disorder: Previous studies have identified hypertension as a risk factor for MI, coronary heart disease, and stroke, with evidence showing that controlling hypertension can reduce the incidence of fatal MI and stroke.40 Additionally, IL-1RN, a member of the interleukin 1 cytokine family, was inferred to be causal for both MI and abdominal aortic aneurysm in our study.