SPDEF and posterior cortical atrophy: Urine exosomes-based dynamic cargo molecules such as ERG, PCA3, and SPDEF mRNAs, promote an aggressive PCa phenotype [15], alongside a spectrum of miRNAs like miRNA-196, miRNA-501, miRNA-34, miRNA-92, miRNA-143-3p (downregulated) [16] and miR-574-3p, miR-141-5p, miR-21-5p (upregulated) [17], crucial for PCa diagnosis.