Detection of high bTMB was associated with a higher estimated tumor fraction: the samples with bTMB≥10 had a median TF of 13.9% (IQR: 4.5-35.1%), while in the 42,776 samples with bTMB<10, the median TF was 1.4% (IQR: 0.0-6.5%). This evidence concerns the gene TF and neoplasm.