In support, a survival analysis from the TCGA database indicated that elevated TGFβ3, GLI2, and YAP1 mRNA levels significantly correlated with an OS rate in bladder cancer patients (p < 0.05), high GLI2 expression decreased the outcome the most with HR of 1.68, TGFβ3 and YAP1 exhibited the HRs of 1.54 and 1.51, respectively (Fig. 1D). The gene discussed is GLI2; the disease is urinary bladder carcinoma.