The third member of the TGY gene signature, YAP1, was selected based on the gene set enrichment analysis where the TGFβ3/GLI2 gene set was significantly associated with the Hippo signaling pathway; in support, YAP1 was shown to induce GLI2 expression in promoting invasive phenotype in breast cancer patients 53. This evidence concerns the gene TGFB3 and breast carcinoma.