TP53 and neoplasm: Additional considerations when gauging the potential that a variant detected by ctDNA CGP is of germline origin include the specific CSG (e.g., the probability that tumor CGP-detected variants are of germline origin is high for some genes, such as BRCA1/2, and low for others, such as tumor protein P53 [TP53] [85]) and the specific variant (e.g., pathogenic founder mutations known to be associated with specific populations [84]).