Univariate Cox regression analysis revealed several statistically significant predictors for survival (P < 0.05), including age, gender, marital status, smoking history, drinking history, family history, BMI, gene mutation, TNM staging, CEA, CYFBA, NSE, SCC, D-dimer, white blood cells, neutrophils, lymphocytes, monocytes, red blood cells, hemoglobin, platelets, NLR, LMR, PLR, bone metastasis, brain metastasis, liver metastasis, lung metastasis, chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Here, SERPINB3 is linked to bone metastasis.