Although the main cause of osteoarthritis was traditionally considered to be the overloading of joints due to excess weight, leading to the destruction of articular cartilage, recent studies have shown that other factors such as adipose deposition, insulin resistance, and, particularly, the improper coordination of innate and adaptive immune responses may lead to the initiation and progression of obesity-associated osteoarthritis (Nedunchezhiyan et al., 2022). This evidence concerns the gene INS and osteoarthritis.