In a study investigating the effect of nano-naringenin on osteoarthritis, nano-naringenin exhibited a potential anti-arthritic activity by reducing the concentrations of serum MMP-3, ADAMTS-5, and joint MDA and increasing the levels of serum TIMP-3 and joint GSH, similar to indomethacin, and the histopathological results confirmed these outcomes. Here, TIMP3 is linked to osteoarthritis.