HF/LVEF ≤ 40%, heart failure/left ventricular ejection fraction ≤ 40%; TIA, transient ischemic attack; NSAIDs, nonsteroidal anti-inflammatory drugs; APAs, antiplatelet agents; ACEIs, angiotensin-converting enzyme inhibitors; ARBs, angiotensin II receptor blockers; ARNIs, neprilysin and angiotensin receptor inhibitors; HCTZ, hydrochlorothiazide; SGLT2, sodium-glucose cotransporter-2 inhibitors. This evidence concerns the gene ACE and heart failure.