TG and neoplasm: Key contributors include age≥ 55 years, male gender, tumor size exceeding 4 cm, follicular histological subtype, extra-thyroidal extension, vascular invasion, lymph node involvement at diagnosis, postoperative serum Tg levels ≥ 10 ng/ml, advanced disease stages (≥ II), high disease risk, and cardiovascular comorbidities (p < 0.05) (Figures 1-3).