Some focused on populations that are not cognitively impaired [7], while others involved dementive conditions like AD [8-10]. These studies reported VNS to be associated with decreased neuroinflammation, decreased cerebral spinal fluid tau proteins, neuroprotective microglial structural changes, and increased neuroplasticity in terms of increased functional connectivity, as well as improvement across a range of cognitive domains. Here, MAPT is linked to Alzheimer disease.