MAPT and Alzheimer disease: Acrolein is a strong electrophilic alpha, beta-unsaturated aldehyde that causes AD-like oxidative damage pathology in the brain, including hyper-phosphorylation of the microtubule-associated protein tau, beta-amyloid aggregation, hippocampal atrophy, behavioral dysfunction, and cognitive decline, including impaired place navigation, among others [12,13].