AF: atrial fibrillation; BPH: benign prostatic hyperplasia; CHF: congestive heart failure; CKD: chronic kidney disease; CM: cardiomyopathy; COPD: chronic obstructive pulmonary disease; CrCl: creatinine clearance; ESRD: end-stage renal disease; F: female; GERD: gastroesophageal reflux disease; HF: heart failure; HT: hypothyroidism; HTN: hypertension; ICD: implantable cardioverter-defibrillator; M: male; NR: not reported; PD: peritoneal dialysis; P-gp: P-glycoprotein; PH: pulmonary hypertension; T2DM: type 2 diabetes mellitus. The gene discussed is ABCB1; the disease is pulmonary arterial hypertension.