PKD1 and Parkinson disease: In the cylinder test, compared with the CTRL group, the ratio of rears was decreased in PD rats, whereas EGCG increased the ratio of rears; moreover, EGCG did not decrease the ratio of rears in PD rats when CID755673 was used to inhibit the PKD1 expression, and Ad-PARP-1 was used to activate the Parthanatos (Figure 2d).