PKD1 and Parkinson disease: In the rotarod test, compared with the CTRL group, the time spent on the rotarod was decreased in PD rats, whereas EGCG increased the time spent on rotarod; moreover, EGCG did not decrease the time spent on rotarod in PD rats when CID755673 was used to inhibit the PKD1 expression and Ad-PARP-1 was used to activate the Parthanatos (Figure 2c).