PKD1 and Parkinson disease: In the pole test, compared with the CTRL group, the descent time was increased in PD rats, whereas EGCG decreased the descent time; moreover, EGCG did not decrease the descent time in PD rats when CID755673 was used to inhibit the PKD1 expression and Ad-PARP-1 was used to activate the Parthanatos (Figure 2h).