In this study, we reported that EGCG can upregulate PKD1 to inhibit Parthanatos to ameliorate the impaired motor function, reduce the expression of TH, suppress the oxidative stress, and suppress the inflammation in SN, suggesting that EGCG may improve the motor impairments via promoting the PKD1 and inhibiting Parthanatos to improve the cell survival of DA neuron in PD. Here, PKD1 is linked to Parkinson disease.