PKD1 and Parkinson disease: In the locomotor activity test, compared with the CTRL group, the counts per 5 min were decreased in PD rats, whereas EGCG increased the counts per 5 min; moreover, EGCG did not decrease the counts per 5 min in PD rats when CID755673 was used to inhibit the PKD1 expression and Ad-PARP-1 was used to activate the Parthanatos (Figure 2g).