In particular, we identified an eight-gene UPR-GS comprising TXNDC5, SSR3, RPN1, PDIA5, HSPA5, OSTC, KDELR2, and YIF1B as a key regulator of tumor aggressiveness and poor survival in bladder cancer patients (Figures 2, 3; Supplementary Figure S2). This evidence concerns the gene HSPA5 and urinary bladder cancer.