HSPA5 and urinary bladder cancer: For instance, HSPA5 has been recently shown to serve as a prognostic marker that promotes the proliferation and metastatic spread of the disease by regulating ferroptosis in bladder cancer (Wang et al., 2023), whereas KDELR2 enhances Golgi-mediated secretion to promote bladder cancer growth and metastasis (Meng et al., 2022).