This is the first instance that TXNDC5 and PDIA5 (genes related to disulfide bond formation-assisted protein folding in ER), SSR3 (a gene related to protein translocation within ER), and OSTC (a gene related to N-linked glycosylation of protein in ER) have been found to be associated with tumor aggressiveness, disease progression, and poor survival in bladder cancer (Figures 2, 3; Supplementary Figure S2). Here, PDIA5 is linked to urinary bladder cancer.