Because we predicted fewer interactions in 6‐month‐old mice (14% of all interactions; Figure 3A,B,D), despite their previously described amyloid‐β pathology at this time point,41 we surmise that CCC in the 3xTg‐AD hippocampus is likely influenced by the duration of amyloid‐β and tau pathology and its long‐term effects. This evidence concerns the gene MAPT and Alzheimer disease.