The 23 AD‐associated ligand–receptor pairs had 6 predicted target genes which were significantly differentially expressed in the 12‐month 3xTg‐AD hippocampus: Lpl, Ptk2b, Mme, Inpp5d, Cacna1c, and Adamts1 (Figure 5B). This evidence concerns the gene CACNA1C and Alzheimer disease.