Because we predicted fewer altered interactions between 3xTg‐AD and WT at 6 months (Figure 3), the number of predicted target genes was overall lower at this time point (Figure 4A,B), although the number of nuclei in our neuronal subpopulations was similar across time points (Figure 2F), further suggesting that CCC becomes increasingly dysregulated with age and/or due to prolonged exposure to amyloid‐β and tau. Here, MAPT is linked to Alzheimer disease.