Considering the subtle changes in CCC in the entorhinal cortex between 2‐ and 8‐month‐old 5xFAD mice74 and the lack of predicted interaction in our 3xTg‐AD hippocampal data at 6 months, it is possible that CCC is less affected by amyloid and more by tau pathology. The gene discussed is MAPT; the disease is amyloidosis.