We generated snRNA‐seq data from the hippocampus of female 3xTg‐AD and age‐matched WT mice at two clinically relevant time points for amyloid‐β plaque formation41 and cognitive impairment95 (by 6 months) and gliosis96 and tau tangle formation41 (by 12 months) to investigate altered glia–neuron communication and their downstream effects throughout disease progression. This evidence concerns the gene MAPT and Alzheimer disease.