Once irradiated by the near-infrared laser, our nanocarrier exhibited superior photothermal conversion, which not only induced photothermal therapy but also facilitated the release of I3C from NBP@mSiO2-PEG-cRGD/I3C within tumor cells to inhibit the activation of proto-oncogenic phosphoinositide 3-kinase (PI3K)-AKT signaling pathway and drive chemotherapy. The gene discussed is AKT1; the disease is neoplasm.