The underlying therapeutic mechanism was deciphered as the efficient photothermal conversion of NBP@mSiO2-PEG-cRGD under irradiation simultaneously induced PTT to combat the tumor and promoted the release of loaded I3C, of which the later inhibited the phosphorylation of AKT by up-regulating the expression of PTEN to inhibit the activation of PI3K-AKT signaling pathway. This evidence concerns the gene AKT1 and neoplasm.