MYH14 and atrial fibrillation: For patients with oHCM who have persistent symptoms attributable to LVOTO despite β-blockers or nondihydropyridine CCB, can add a myosin inhibitor (adult patients only), or disopyramide, or SRT performed at experienced centers. Since disopyramide can enhance atrioventricular node conduction and has the potential to increase ventricular rate during AF episodes, it is recommended to use disopyramide in combination with β-blockers or verapamil/diltiazem