In order to analyze the correlation between targeted therapy and pyroptosis of lung cancer, Lu et al. use western blot analysis, phase contrast imaging, scanning electron microscope, and flow cytometry to analyze the cell death models of A549 (KRAS-G12S mutation), PC9 (EGFR19 exon deletion mutation), and NCI-H3122 (EML4-ALK fusion gene) lung cancer cell lines and xenotransplantation models after targeted therapy. Here, ALK is linked to lung carcinoma.