The top five core genes—namely, CASP1 (caspase1), PYCARD (PYD and CARD domain-containing protein), NLRP3 (NOD-like receptor protein 3), AIM2 (absent in melanoma 2), and NLRP1 (NOD-like receptor protein 1)—related to lung adenocarcinoma pyroptosis were selected. The gene discussed is AIM2; the disease is lung adenocarcinoma.