However, there is strong evidence supporting the following associations: (1) Higher genetic prediction levels of AZGP1 are negatively associated with CHF risk; (2) higher genetic prediction levels of ALDH2 are positively associated with IS risk; and (3) higher genetic prediction levels of APOE, JAG1, MCL1, PIP4K2A, and RAB1A are positively associated with T2DM risk, and higher genetic prediction levels of PTPN9 and SNUPN are inversely associated with T2DM risk. The gene discussed is APOE; the disease is type 2 diabetes mellitus.