(2) In the case of CHF, the protein PLG (plasminogen) [OR = 1.21, 95% CI (1.10–1.33), p‐fdr = 0.048] showed a positive causal relationship, suggesting a potential association with an increased risk of CHF; AZGP1 (alpha-2-glycoprotein 1, zinc-binding protein) [OR = 0.83, 95% CI (0.76–0.91), p‐fdr = 0.048] exhibited a negative causal relationship, indicating that it may act as a protective protein against CHF. This evidence concerns the gene PLG and congestive heart failure.