The failure to resolve infection allows the virus to reach the CNS, where it causes severe inflammation, neuronal death, and breakdown of the BBB, and TLRs, TLR3 and TLR7, detect viral RNA in endosomes, triggering a similar IFN response through adaptor proteins, such as TRIF, or a myeloid differentiation primary response.88 The gene discussed is IFNA1; the disease is infection.