CDKN1A and epilepsy: In addition, we found that the expression of P21, CCL2, and NFKBIA are substantially enriched in SMI expressing histopathological neurons compared with Pan-neuronal nuclei– expressing (NeuN-expressing) neurons in brain tissue in FCD (Figure 4, A and B), but not expressed in cortical neurons in control brain tissue with no history of epilepsy (Figure 4, C and D, and Supplemental Figure 6, C and D).