Our results revealed the expression of senescent cell markers P21, P53, COX2, γ-H2AX, and SA-β-Gal, and reduction of the nuclear integrity marker Lamin B1 in SMI-expressing histopathological neurons in patients with drug-resistant epilepsy with different pathologies, but not in control brain tissue with no history of epilepsy. The gene discussed is TP53; the disease is epilepsy.