In addition, the expression of P53, γ-H2AX, and COX2 are substantially enriched in SMI-expressing histopathological neurons compared with NeuN-positive neurons in brain tissue in FCD (Figure 5, D and F), but not expressed in cortical neurons in control brain tissue with no history of epilepsy (Figure 5, E and G, and Supplemental Figure 6). Here, PTGS2 is linked to epilepsy.