The immediate early genes including (EGR2, EGR3, JUN) dual-specificity kinase/phosphotase MKP-3 (DUSP6) are highly expressed in the PY2 pyramidal neurons (Figure 1D and Supplemental Figure 1B; supplemental material available online with this article; https://doi.org/10.1172/JCI188942DS1), consistent with the expression of activity-dependent genes in cortical neurons in drug-resistant epilepsy (22). The gene discussed is EGR3; the disease is epilepsy.