CCN2 and neoplasm: Moreover, HUVECs cocultured with CRC patient–derived monocytes exhibited enhanced migratory ability, tube-forming capacity, and tumor cell transendothelial migratory ability (Supplemental Figure 17, B and C) and increased expression levels of YAP downstream genes CTGF, CYR61, and ANKRD1 (Supplemental Figure 17D).