TNFRSF4 and neoplasm: However, conditional OX40 overexpression in ECs promoted angiogenesis (Supplemental Figure 3, A and B), and enhanced tumor growth (Figure 2G) and metastasis (Figure 2H); OX40L treatment further aggravated angiogenesis (Supplemental Figure 3, A and B) and tumor-promoting effects (Figure 2, G and H).