MBTPS1 and neoplasm: Importantly, verteporfin markedly disrupted the tumor-promoting role in vivo (Figure 7C), and the migratory ability (Supplemental Figure 12C), tube-forming capacity (Supplemental Figure 12D), and tumor cell transendothelial migratory ability of ECs (Supplemental Figure 12E) induced by exogenous S1P supplementation.