scRNA-Seq data showed that tumor-promoting genes associated with cell proliferation, stemness, metastasis, drug resistance, and key transcription factors (TFs) were upregulated in OX40+ ECs from CRC tissues, whereas important tumor suppressors, including RB, BAD, and FAS, were markedly reduced (Supplemental Figure 2A). Here, RB1 is linked to colorectal carcinoma.