Meersch et al. found that pediatric patients with congenital heart disease had elevated urinary TIMP-2*IGFBP7 values before cardiac surgery (mean 0.9–1.0) with values decreasing to 0.4–0.5 one day after surgery, suggesting that either preoperative venous congestion or fasting could affect renal integrity [56]. The gene discussed is IGFBP7; the disease is congenital heart disease.