Two different cut-off values (0.3 and 2.0 ng/ml2/1000) of TIMP-2*IGFBP7 were validated in critically-ill adult patients [14, 53], showing that patients with TIMP-2*IGFBP7 value > 0.3 had a seven-fold increase in AKI risk [14] and that the risk of death, dialysis or recurrent renal dysfunction in patients with AKI was doubled for values above 2.0 [15]. The gene discussed is IGFBP7; the disease is acute kidney injury.