INS and diabetic ketoacidosis: Typically, younger age (< 7 years) is associated with a lower proportion of residual insulin-containing islets, serum C-peptide levels; higher proinsulin- to–C-peptide ratios, and frequency of diabetic ketoacidosis; hyperimmune CD20hi pattern of insulitis; HLA-DR3/DR4 haplotypes; and higher overall number of autoantibodies when compared to those diagnosed at aged ≥ 13 years [6].