Another result of our study is that these more severe phenotypes of MSA showed higher NfL levels: 1- on the whole sample, MSA patients with early stridor and/or RBD onset, showed higher CSF NfL than those with late stridor and RBD onset; 2- in the stridor subgroup, patients with early stridor onset showed higher CSF NfL levels than those with late stridor onset even if without reaching statistical significance. Here, NEFL is linked to multiple system atrophy.