TRPM6 and metabolic syndrome: Furthermore, fructose, fructose + dapagliflozin, and fructose + magnesium diets/treatments seemingly increased the TRPM6 protein expression in all localizations, which supports the involvement of TRPM6 in both physiological and pathophysiological states including metabolic syndrome, that may potentially not be restricted to DCTs (Ng et al. 2021).