This is very different from other anti-MPNST agents, including chemotherapeutic agent doxorubicin (Fig. 1C), BET bromodomain inhibitor JQ-1 (Fig. 1D), and SHP2 Inhibitor SHP099 (Fig. 1E); these agents induce apoptotic cell death or arrest cell cycle in MPNST [22–24]. The gene discussed is PTPN11; the disease is malignant peripheral nerve sheath tumor.