UPP1 and liver failure: The experimental results showed that after treatment, Tymp/Upp1 promoted the synthesis and secretion of TYMP mRNA and active enzymes in the liver in Tymp/Upp1 mice, resulting in an effective decrease in plasma nucleoside levels that persisted for 1 year.438 Similarly, Battani et al. investigated mitochondrial hepatocerebral disease and delivered the MPV17 into an MPV17 knockout mouse model gene using AAV8; the supramolecular complex level of MPV17 was effectively restored, and the progression of liver failure was delayed.439