Upregulated LCN2 is associated with a variety of central nervous system diseases, such as acute brain injury ischemic stroke, hemorrhagic stroke, traumatic brain injury, and neurodegenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and vascular dementia (VaD) [36–39]. This evidence concerns the gene LCN2 and early-onset autosomal dominant Alzheimer disease.