SIRT3, an NAD+-dependent deacetylase primarily localized in mitochondria, plays a pivotal role in various biological processes such as cellular metabolism, stress response, cell cycle, and mitophagy.52 Therefore, we hypothesized that restoring SIRT3 expression may alleviate bone loss in T2DM mice via recuperating PINK1/PRKN-mediated mitophagy. Here, SIRT3 is linked to type 2 diabetes mellitus.