Nonetheless, oral administration of lipids increases lipid storage in global Gipr deficient mice [803], which is in line with the observation that GIP induces lipolysis under conditions where insulin action is low to absent [597,598,769,[794], [795], [796]], and that mice with adipocyte-specific overexpression of Gipr show decreased fat mass and protection from diet-induced obesity [799]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.