GIPR and Insulin resistance: In contrast, deletion of Gipr in immune cells augments adipose tissue inflammation and insulin resistance, whereas co-deletion of GIPR and S100A8/A9 in immune cells ameliorates the dysregulated metabolic and inflammatory phenotypes observed in HFD-fed mice with myeloid deletion of Gipr, consistent with a suppressive role for GIP in the control of myeloid cell mediated adipose tissue inflammation [784].