Accordingly, GLP-1R agonists do not induce hypoglycemia in people living with T2D, unless Ca2+ influx is increased by adjunctive therapy with sulfonylureas, which induce β-cell membrane depolarization independent of the ambient glucose concentration [[675], [676], [677], [678], [679], [680], [681], [682]]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.