Interestingly, the silencing of STK25 in Hep3B cells decreased the activation of mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinase 1/2 (ERK1/2), and Jun N-terminal kinase (JNK), which are key signaling components promoting proliferation and migration in human HCC,35, 36, 37 whereas the phosphorylation status of p38 MAPK remained unaffected (Figure 21). The gene discussed is MAPK8; the disease is hepatocellular carcinoma.