Similarly to STK25, MST3 and MST4 bind to hepatocellular lipid droplets and have been identified as drivers of hepatic steatotoxicity and tumorigenicity based on expression profiling in liver biopsies from subjects with MASH and MASH-related HCC as well as in vitro investigations in cultured human hepatocytes.15 The gene discussed is STK24; the disease is hepatocellular carcinoma.