In rat diabetic Achilles’ tendons or high glucose (HG)-treated tenocytes derived from them, hyperglycemia caused disorganized collagen fiber arrangement, augmented ROS levels concomitant to increased expression of NOX1 and NOX4 mRNA, MMP2, TIMP2, and collagen III expression additionally inducing a pro-inflammatory state as seen by increased levels of IL6 [[38], [39], [40], [41]]. This evidence concerns the gene IL6 and Hyperglycemia.