In line with this, PXR deficiency promoted diethylnitrosamine-induced hepatic cancer and decreased survival in PXR-KO mice (Shi et al, 2024), whereas overexpression of PXR was shown to diminish the malignancy of human cancer cell lines by reducing cell migration, adhesion, and invasion (Kotiya et al, 2016). The gene discussed is NR1I2; the disease is cancer.