Of note, as observed in our BCP‐ALL cell lines (Figure 3b,c), four (SP6, CCNE1, HIST1H2BH, and DECR2) and two (EVI2B and SYN1) genes were significantly higher and lower in the samples at relapse than in those at diagnosis, respectively (Figure S2). Here, SP6 is linked to acute lymphoblastic leukemia.