In this cross‐sectional study, we found higher VWF:Ag levels in all groups—ischemic stroke (group 1), migraine with aura (group 2), and ischemic stroke and migraine (group 3)—compared with the reference group (group 4), with 31% higher levels in the ischemic stroke and migraine group (group 3), statistically significantly higher than in the groups with only stroke (group 1) or only migraine with aura (group 2). Here, VWF is linked to ischemic stroke.