For the cerebrovascular diseases, a higher plasma level of HIF‐1α was associated with a decreased incidence of CES (odds ratio [OR] = 0.885; 95% confidence interval [CI] = 0.796−0.985, p = 0.026) in the IVW method (Figure 2), with a statistical power of 88% (Table S2). The gene discussed is HIF1A; the disease is cerebrovascular disorder.