Under the IVW model, higher plasma HIF‐1α levels were negatively associated with the risk of migraine (OR = 0.941, 95% CI = 0.888–0.998, p = 0.041) and MOAD (OR = 0.586, 95% CI = 0.375–0.916, p = 0.019) (Figure 2). Here, HIF1A is linked to migraine disorder.