2012). Compared to other stroke subtypes, CES has a more inflammatory environment, macrophage content, and greater platelet content in thrombus (Maida et al. 2020). Furthermore, several studies have shown that HIF‐1α activates downstream genes to control hypoxia responses, promote blood vessel growth, improve myocardial infarction, and increase the survival rate of patients with acute myocardial ischemia (Zheng et al. 2018; Jianqiang et al. 2015). The gene discussed is HIF1A; the disease is Stroke.