ZNF746 and Anxiety: However, when PARIS was expressed in midbrain dopaminergic neurons, the 3-month-old PARIS Tg mice developed a slightly increased total distance and 2- and 3-month-old PARIS Tg mice showed anxiety, as shown by the increased percentage of time spent in the border zone relative to that spent at the central areas of the open field arena (Supplementary Fig. 3F–H).