Beyond dopamine, changes in the expression of PD-associated genes and alterations in the proportions of glutamatergic, cholinergic, GABAergic, and serotonergic neuronal subtypes were observed in PARIS Tg mice compared to controls, suggesting a broader disruption of neurotransmission that may contribute to PD-associated phenotypic disturbances [50]. This evidence concerns the gene ZNF746 and Parkinson disease.