The findings of intragroup and intergroup comparisons of pretreatment and posttreatment in the high‐ and low‐efficacy groups revealed that comprehensive acupuncture intervention reduced NIHSS scores and muscle strength scores of the affected limbs of patients with cerebral infarction who underwent intravenous thrombolysis with r‐tPA and effectively enhanced both neurological and motor functions in patients after treatment. This evidence concerns the gene PLAT and brain infarction.