Recent evidence also supports the involvement of the epithelial cytokines such as thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33, upstream cytokines known as bronchial epithelial cell-derived alarmins, in asthma airway remodeling through the activation of different immune and or structural cells [18–19]. The gene discussed is TSLP; the disease is asthma.