The data confirmed the relevance of laminins, showing a positive correlation with CIN (LAMA1: r 0·84, p < 0·001; LAMB1: r 0·802, p < 0·001; LAM C1: r 0·83, p < 0·001) as well as CDC42 (r 0·52, p < 0·05). This evidence concerns the gene CDC42 and cervical squamous intraepithelial neoplasia.