Many of the genes found in the top 100 were previously associated with CIN for their role in the dynamic of mitotic spindle (NSMCE2[24]), the kinetochore-microtubule complex (FDG1[25]) and the regulation of ploidy (NUAK1 [26]). The gene discussed is NSMCE2; the disease is cervical squamous intraepithelial neoplasia.