Cluster 1, related with mitochondrial metabolism, contained many proteins linked to acyltransferase activity and FAO, confirming their correlation with CIN but with two new acyltransferases: ACAA2 (r 0·73, p < 0·001), a rate-limiting enzyme catalysing the last step of the mitochondrial beta-oxidation pathway, and ACAT1 (r 0·61, p < 0·01), a key rate-limiting enzyme in ketone body metabolism responsible for recycling ketone bodies into acetyl-CoA, reinforcing a process already highlighted in the integrative analysis. The gene discussed is ACAA2; the disease is cervical squamous intraepithelial neoplasia.