For instance, in Glanzmann thrombasthenia, an autosomal recessive genetic disease, asymptomatic carriers who are heterozygous for the causative gene (ITGA2B or ITGB3) tend to have a lower expression of integrin glycoprotein IIb-IIIa on the platelet surface than those in the control group [38]. This evidence concerns the gene ITGA2B and Glanzmann thrombasthenia 1.